Research Journal of Pharmacy and Technology

Vikram Kumar Sahu ¹, Amit Mishra ¹, Nitin Sharma ², Pratap Kumar Sahu ³, Shubhini A. Saraf ⁴

Affiliations
1 Maharana Pratap College of Pharmacy, Kanpur, 209217, IN
2 Meerut Institute of Engineering and Technology, NH- 58, Baghpat Crossing, Partapur Bypass Road, Meerut, 250005,, IN
3 School of Pharmaceutical Sciences, Siksha 'O' Anusandhan University, Bhubaneswar, 751030, IN
4 Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Lucknow, 226025, IN

Abstract

In the present work dry polysaccharides were extracted from two traditional plants, fenugreek (Trigonella Foenum graecum) and tamarind (Tamarindus indica). Both extracted polysaccharide were subjected for several parameter to find out their suitability used as pharmaceutical excipients. Polysaccharides were evaluated for their physicochemical parameters which revealed an acceptable range of micrometric properties. Mean value of total percentage glucose concentration in fenugreek and tamarind was calculated 23.5±4.72 and 31.9±6.32 respectively. Molecular weight of fenugreek and tamarind was estimated by refractive index method which found to be 2.03x10^-6 and 1.79 x 10⁶ kg/kg mol respectively. Rheological study indicates that aqueous solution of both polysaccharide possessed non-newtonian pseudoplastic flow behavior. Finally, cell viability assay confirm that both polysaccharide may be considered as safe excipients during drug delivery. The study confirmed that both plat polysaccharides (Trigonella foenum graecum) and (Tamarindus indica) can be considered as effective pharmaceutical excipients for the preparation of novel drug delivery systems.

Keywords

Trigonella foenum graecum, Tamarindus indiaca, Rheology, Brookfield Rheometer, Pseudoplastic.

Full Text

     

Prashant Tiwari ¹, Susmita Jena ¹, Swaroop Satpathy ¹, Pratap Kumar Sahu ¹

Affiliations
1 Department of Pharmacology, School of Pharmaceutical Sciences, Siksha O Anusandhan (Deemed to be University), Bhubaneswar-751029, IN

Abstract

Nigella sativa belonging to family ranunculaceae. This plant is an extensively used as medicinal plant in India as well as all over the world. Nigella sativa (N. sativa) is well known plant of traditional systems of medicine such as Ayurveda, Siddha and Unani. It is also known as nutmeg flower, black seed, black cumin, black caraway, fennel flower, roman coriander, and kalonji. Alkaloids, phenols, flavonoids, glycosides, terpenoids and steroids are the important phyto constituents of N. sativa. The active constituents of N. sativa are thymohydroquinone, p-cymene, dithymoquinone, thymoquinone, carvacrol, sesquiterpene longifolene. N. sativa seed also contains pentacyclic triterpene, alpha-hederin, protein, carbohydrates, crude fibre, fat and saponin. N. sativa oil contains oleic acid, palmitic acid, linoleic acid. Aromatics contain α-thujene, thymol, α-pinene, thymoquinone, dihydrothymoquinone. N. sativa has been used as stimulant, emmenagogue, appetizer, pungent, anthelmintic, pungent, deodorant, carminative, purgative, expectorant, febrifuge, deodorant etc. N. sativa possess numerous pharmacological action such as antibacterial, antifungal, anticancer, hepatoprotective, antioxidant, antiinflammatory, analgesic, immunomodulatory, antidiabetic, dyslipidemia, antiepileptic, gastroprotective, antioxytocic, anti-fertility, respiratory, dermatological, nephroprotective, antiviral, testicular-protective, antidepressant and anticonvulsant activity. So considering the medicinal value and its therapeutic potential this review article would spotlight on phytochemistry, chemical composition and pharmacological activity of N. sativa.

Keywords

Nigella sativa, Phytochemistry, Black Seed, Nutmeg Flower, Pharmacological Activity.

Full Text